Furthermore, a strategy which combines personal protection and adulticide controls is found to be the most cost-effective control strategy. Cessation of tobacco use, reduction of salt in the diet, eating more fruit and vegetables, regular physical activity and avoiding harmful use of alcohol have been shown to reduce the risk of cardiovascular disease. The role of the enigmatic variant fibrinogen gamma chain has also become clearer. In the case of model with time-dependent control functions, the optimality levels of the three control functions required to optimally control dengue disease transmission are derived.Ĭonclusion We conclude that dengue fever transmission can be curtailed by adopting any of the several control strategies analysed in this study. Inhibition of gamma chain function with the monoclonal antibody 7E9 has been shown to interfere with multiple fibrinogen activities, including factor XIIIa crosslinking, platelet adhesion, and platelet-mediated clot retraction. It also reveals that the biologically realistic disease-free equilibrium is both locally and globally asymptotically stable whenever the inequality R ˜ 0 < 1holds. In addition, cost-effectiveness analysis is performed to determine the most cost-effective strategy among the various control strategies analysed.Īnalysis of the model with control parameters shows that the model has two disease-free equilibria, namely, trivial equilibrium and biologically realistic disease-free equilibrium, and one endemic equilibrium point. The resulting optimality system is simulated in MATLAB using fourth order Runge-Kutta scheme based on the forward-backward sweep method. In a bid to optimally curtail dengue fever propagation, we apply optimal control theory to investigate the effect of several control strategies of combination of optimal personal protection, larvicide and adulticide controls on dengue fever dynamics.
The model is fitted to the data related to the 2012 dengue outbreak in Johor, Malaysia, using the least-squares method. Comparison theorem is used to analyse the global dynamics of the model. The control-induced basic reproduction number ( R ˜ 0) related to the model is computed using the next generation matrix method. Hence, the use of mathematical model to gain insights into the transmission dynamics and derive the optimal control strategies for minimizing the spread of the disease is of great importance.Ī model involving eight mutually exclusive compartments with the introduction of personal protection, larvicide and adulticide control strategies describing dengue fever transmission dynamics is presented. Beryllium-7 measurements were used as a quality control for the performance of the sampling system.
The disease is presently a public health issue in the country. after which it is returned to NRL for gamma spectrometric analysis. Dengue is a vector-borne viral disease endemic in Malaysia. Use of Gamma Control 5 means that you have loaded, installed, or run Gamma Control 5 on a computer or similar device.
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